Chromatin immunoprecipitation-mediated target identification proved aquaporin 5 is regulated directly by estrogen in the uterus.

@article{Kobayashi2006ChromatinIT,
  title={Chromatin immunoprecipitation-mediated target identification proved aquaporin 5 is regulated directly by estrogen in the uterus.},
  author={Mika Kobayashi and Eri Takahashi and Shin-ichi Miyagawa and Hajime Watanabe and Taisen Iguchi},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2006},
  volume={11 10},
  pages={1133-43}
}
Estrogens play a central role in the reproduction of vertebrates and affect a variety of biological processes. The major target molecules of estrogens are nuclear estrogen receptors (ERs), which have been studied extensively at the molecular level. In contrast, our knowledge of the genes that are regulated directly by ERs remains limited, especially at the level of the whole organism rather than cultured cells. In order to identify genes that are regulated directly by ERs in vivo, we used… CONTINUE READING

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