Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo.

@article{Pillai2015ChromatinIA,
  title={Chromatin immunoprecipitation assays: analyzing transcription factor binding and histone modifications in vivo.},
  author={Smitha R Pillai and Piyali Dasgupta and Srikumar Chellappan},
  journal={Methods in molecular biology},
  year={2015},
  volume={1288},
  pages={429-46}
}
Studies in the past decade have shown that differential gene expression depends not only on the binding of specific transcription factors to discrete promoter elements but also on the epigenetic modification of the DNA as well as histones associated with the promoter. While techniques like electrophoretic mobility shift assays could detect and characterize the binding of specific transcription factors present in cell lysates to DNA sequences in in vitro binding conditions, they were not… CONTINUE READING

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