Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

@inproceedings{Zylicz2015ChromatinDA,
  title={Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development},
  author={Jan J Zylicz and Sabine Dietmann and Ufuk G{\"u}nesdogan and Jamie A Hackett and Delphine Cougot and Caroline LG Lee and M. Azim Surani},
  booktitle={eLife},
  year={2015}
}
Early mouse development is accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2), which is essential for embryonic development. Here we show that genome-wide accumulation of H3K9me2 is crucial for postimplantation development, and coincides with redistribution of enhancer of zeste homolog 2 (EZH2)-dependent histone H3 lysine 27 trimethylation (H3K27me3). Loss of G9a or EZH2 results in upregulation of distinct gene sets… CONTINUE READING
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