Chromatin domains, insulators, and the regulation of gene expression.

  title={Chromatin domains, insulators, and the regulation of gene expression.},
  author={Rodolfo Ghirlando and Keith M. Giles and Humaira Gowher and Tiaojiang Xiao and Zhixiong Xu and Hongjie Yao and Gary Felsenfeld},
  journal={Biochimica et biophysica acta},
  volume={1819 7},
The DNA sequence elements called insulators have two basic kinds of properties. Barrier elements block the propagation of heterochromatic structures into adjacent euchromatin. Enhancer blocking elements interfere with interaction between an enhancer and promoter when placed between them. We have dissected a compound insulator element found at the 5' end of… CONTINUE READING