Chromatin diminution in nematodes

@article{Muller1996ChromatinDI,
  title={Chromatin diminution in nematodes},
  author={Fritz Müller and V D Bernard and Heinz Tobler},
  journal={BioEssays},
  year={1996},
  volume={18}
}
The process of chromatin diminution in Parascaris and Ascaris is a developmentally controlled genome rearrangement, which results in quantitative and qualitative differences in DNA content between germ line and somatic cells. Chromatin diminution involves chromosomal breakage, new telomere formation and DNA degradation. The programmed elimination of chromatin in presomatic cells might serve as an alternative way of gene regulation. We put forward a new hypothesis of how an ancient partial… Expand
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A hypothesis is presented as to how, during evolution, a partial genome duplication might have been linked to the process of chromatin diminution, in order to provide a selective advantage to parasitic DNA-eliminating nematodes. Expand
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It is postulate that ciliate nuclear restructuring serves to segregate the two essential functions of chromosomes: the transmission and expression of genetic information. Expand
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TLDR
Data suggest that DNA elimination likely evolved independently in these nematodes and indicates that differential CENP-A deposition within chromosomes defines which sequences are retained and lost during Ascaris DNA elimination. Expand
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Chromatin diminution in Parascaris and Ascaris represents the classical case of a developmentally programmed genome rearrangement that involves chromosomal breakage, new telomere formation and DNA degradation. Expand
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TLDR
The prototype sequence of the DNA which is eliminated in the course of chromatin diminution in Ascaris suum is determined and the overall structure of this germ line limited DNA corresponds to the segmental organization characteristic of satellite DNAs. Expand
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TLDR
A cDNA clone that codes for a putative ribosomal protein (ALEP-1) indicates a difference in germ-line and somatic ribosomes of A. lumbricoides and P. equorum, and may represent an alternative way to gene regulation. Expand
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TLDR
The results presented here show that the germline DNA of Ascaris contains highly repetitive components, eliminated by the diminution process, and their possible molecular function in connection with germline–soma differentiation and chromosomal behaviour is discussed. Expand
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TLDR
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TLDR
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The chromosomes of this organism possess a particular centromeric organization and undergo a process known as chromatin diminution in all presomatic cells during early development, which makes Parascaris a good model to study general aspects of chromosome biology. Expand
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TLDR
A cytological analysis by modern banding techniques of gonial metaphases in two Parascaris forms that have been considered varieties but now seem to be two species reveals a different chromosome organization in each. Expand
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