Chromatin-dependent cooperativity between site-specific transcription factors in vivo.

@article{Hebbar2007ChromatindependentCB,
  title={Chromatin-dependent cooperativity between site-specific transcription factors in vivo.},
  author={Pratibha B. Hebbar and Trevor K Archer},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 11},
  pages={8284-91}
}
Accessing binding sites in DNA wrapped around histones in condensed chromatin is an obstacle that transcription factors must overcome to regulate gene expression. Here we demonstrate cooperativity between two transcription factors, the glucocorticoid receptor (GR) and nuclear factor 1 (NF1) to bind the mouse mammary tumor virus promoter organized as regular chromatin in vivo. This cooperativity is not observed when the promoter is introduced transiently into cells. Using RNA interference to… CONTINUE READING

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