Chromatin crosstalk in development and disease: lessons from REST

@article{Ooi2007ChromatinCI,
  title={Chromatin crosstalk in development and disease: lessons from REST},
  author={L. Ooi and I. Wood},
  journal={Nature Reviews Genetics},
  year={2007},
  volume={8},
  pages={544-554}
}
  • L. Ooi, I. Wood
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Genetics
  • Protein complexes that contain chromatin-modifying enzymes have an important role in regulating gene expression. Recent studies have shown that a single transcription factor, the repressor element 1-silencing transcription factor (REST), can act as a hub for the recruitment of multiple chromatin-modifying enzymes, uncovering interdependencies among individual enzymes that affect gene regulation. Research into the function of REST and its corepressors has provided novel insight into how… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 134 REFERENCES
    Chromatin Modifications and Their Function
    • 8,719
    • PDF
    Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
    • 4,012
    • PDF