Chromatin conformation signatures: ideal human disease biomarkers?

@article{Crutchley2010ChromatinCS,
  title={Chromatin conformation signatures: ideal human disease biomarkers?},
  author={Jennifer Lynn Crutchley and Xue Qing David Wang and Maria A. Ferraiuolo and Josee Dostie},
  journal={Biomarkers in medicine},
  year={2010},
  volume={4 4},
  pages={
          611-29
        }
}
Human health is related to information stored in our genetic code, which is highly variable even amongst healthy individuals. Gene expression is orchestrated by numerous control elements that may be located anywhere in the genome, and can regulate distal genes by physically interacting with them. These DNA contacts can be mapped with the chromosome conformation capture and related technologies. Several studies now demonstrate that gene expression patterns are associated with specific chromatin… CONTINUE READING

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