Chromatin association of replication protein A.

  title={Chromatin association of replication protein A.},
  author={Kai Treuner and Carmen Eckerich and Rolf Knippers},
  journal={The Journal of biological chemistry},
  volume={273 48},
Replication protein A (RPA) is the major single strand-specific DNA-binding protein in eukaryotic cells. We have investigated the distribution of RPA in nuclei of proliferating HeLa cells and found that only one-third of the detectable RPA appeared to be bound to DNA in chromatin, whereas the remainder was free in the nucleosol. This distribution did not significantly change when cells were released from a double thymidine block into the S phase of the cell cycle. Single strand-specific… CONTINUE READING

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