Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.

@article{Sutcliffe2011ChromatinassociatedPK,
  title={Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.},
  author={Elissa L. Sutcliffe and Karen L Bunting and Yi Qing He and Jasmine Li and Chansavath Phetsouphanh and Nabila Seddiki and Anjum Zafar and Elizabeth J. Hindmarsh and Christopher Richard Parish and Anthony D. Kelleher and Russell L McInnes and Toshiki Taya and Peter John Milburn and Sudha Rao},
  journal={Molecular cell},
  year={2011},
  volume={41 6},
  pages={704-19}
}
Studies in yeast demonstrate that signaling kinases have a surprisingly active role in the nucleus, where they tether to chromatin and modulate gene expression programs. Despite these seminal studies, the nuclear mechanism of how signaling kinases control transcription of mammalian genes is in its infancy. Here, we provide evidence for a hitherto unknown function of protein kinase C-theta (PKC-θ), which physically associates with the regulatory regions of inducible immune response genes in… CONTINUE READING

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