Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.

  title={Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.},
  author={E. Sutcliffe and Karen L. Bunting and Y. Q. He and Jasmine Li and Chansavath Phetsouphanh and N. Seddiki and A. Zafar and E. Hindmarsh and C. Parish and A. Kelleher and R. Mcinnes and T. Taya and P. Milburn and Sudha Rao},
  journal={Molecular cell},
  volume={41 6},
  • E. Sutcliffe, Karen L. Bunting, +11 authors Sudha Rao
  • Published 2011
  • Biology, Medicine
  • Molecular cell
  • Studies in yeast demonstrate that signaling kinases have a surprisingly active role in the nucleus, where they tether to chromatin and modulate gene expression programs. Despite these seminal studies, the nuclear mechanism of how signaling kinases control transcription of mammalian genes is in its infancy. Here, we provide evidence for a hitherto unknown function of protein kinase C-theta (PKC-θ), which physically associates with the regulatory regions of inducible immune response genes in… CONTINUE READING
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    Publications referenced by this paper.
    A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression
    • 414
    Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in β-cells
    • 68
    • PDF
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    • 157
    • 327
    Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression
    • 547
    • Highly Influential
    A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression.
    • 220
    • Highly Influential
    Multiple biological responses activated by nuclear protein kinase C
    • 98
    Multilayered control of gene expression by stress‐activated protein kinases
    • 135
    • PDF
    PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation
    • 122
    • PDF