Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.

@article{Sutcliffe2011ChromatinassociatedPK,
  title={Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.},
  author={E. Sutcliffe and Karen L. Bunting and Y. Q. He and Jasmine Li and Chansavath Phetsouphanh and N. Seddiki and A. Zafar and E. Hindmarsh and C. Parish and A. Kelleher and R. Mcinnes and T. Taya and P. Milburn and Sudha Rao},
  journal={Molecular cell},
  year={2011},
  volume={41 6},
  pages={
          704-19
        }
}
  • E. Sutcliffe, Karen L. Bunting, +11 authors Sudha Rao
  • Published 2011
  • Biology, Medicine
  • Molecular cell
  • Studies in yeast demonstrate that signaling kinases have a surprisingly active role in the nucleus, where they tether to chromatin and modulate gene expression programs. Despite these seminal studies, the nuclear mechanism of how signaling kinases control transcription of mammalian genes is in its infancy. Here, we provide evidence for a hitherto unknown function of protein kinase C-theta (PKC-θ), which physically associates with the regulatory regions of inducible immune response genes in… CONTINUE READING
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