Chromatin assembly during DNA replication in somatic cells.

  title={Chromatin assembly during DNA replication in somatic cells.},
  author={Torsten Krude},
  journal={European journal of biochemistry},
  volume={263 1},
Newly replicated DNA is assembled into chromatin through two principle pathways. Firstly, parental nucleosomes segregate to replicated DNA, and are transferred directly to one of the two daughter strands during replication fork passage. Secondly, chromatin assembly factors mediate de-novo assembly of nucleosomes on replicating DNA using newly synthesized and acetylated histone proteins. In somatic cells, chromatin assembly factor 1 (CAF-1) appears to be a key player in assembling new… CONTINUE READING