Chromatin architectures at fission yeast transcriptional promoters and replication origins

@inproceedings{Givens2012ChromatinAA,
  title={Chromatin architectures at fission yeast transcriptional promoters and replication origins},
  author={Robert M. Givens and William K. M. Lai and Jason M. Rizzo and Jonathan E. Bard and Piotr A. Mieczkowski and Janet K. Leatherwood and Joel A. Huberman and Michael J. Buck},
  booktitle={Nucleic acids research},
  year={2012}
}
We have used micrococcal nuclease (MNase) digestion followed by deep sequencing in order to obtain a higher resolution map than previously available of nucleosome positions in the fission yeast, Schizosaccharomyces pombe. Our data confirm an unusually short average nucleosome repeat length, ∼152 bp, in fission yeast and that transcriptional start sites (TSSs) are associated with nucleosome-depleted regions (NDRs), ordered nucleosome arrays downstream and less regularly spaced upstream… CONTINUE READING

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