Chromatin alterations surrounding the BCR/ABL fusion gene in K562 cells.

@article{SchaeferRego1990ChromatinAS,
  title={Chromatin alterations surrounding the BCR/ABL fusion gene in K562 cells.},
  author={K E Schaefer-Rego and David Leibowitz and John Gregory Mears},
  journal={Oncogene},
  year={1990},
  volume={5 11},
  pages={1669-73}
}
Chronic myelogenous leukemia (CML) is characterized by the presence of a novel fusion gene comprised of portions of the BCR gene from chromosome (ch) 22 and the ABL gene from ch 9. The present study was designed to identify regulatory DNA regions as determined by DNAase I hypersensitivity to address the question of whether altered chromatin contributes to changes in ABL expression. We identify five hypersensitive (HS) sites within the abnormal BCR/ABL allele in K562 cells in a pattern different… CONTINUE READING