Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity

@inproceedings{Tewari2012ChromatinAR,
  title={Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity},
  author={Alok K. Tewari and Galip G{\"u}rkan Yardimci and Yoichiro Shibata and Nathan C. Sheffield and Lingyun Song and Barry S. Taylor and Stoyan Georgiev Georgiev and Gerhard A. Coetzee and Uwe Ohler and Terrence S. Furey and Gregory E. Crawford and Phillip G. Febbo},
  booktitle={Genome Biology},
  year={2012}
}
Epigenetic mechanisms such as chromatin accessibility impact transcription factor binding to DNA and transcriptional specificity. The androgen receptor (AR), a master regulator of the male phenotype and prostate cancer pathogenesis, acts primarily through ligand-activated transcription of target genes. Although several determinants of AR transcriptional specificity have been elucidated, our understanding of the interplay between chromatin accessibility and AR function remains incomplete. We… CONTINUE READING
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