Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

@article{Liu2013ChromatinMA,
  title={Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging},
  author={L. Liu and T. Cheung and G. Charville and Bernadette Marie Ceniza Hurgo and Tripp Leavitt and Johnathan Shih and A. Brunet and T. Rando},
  journal={Cell reports},
  year={2013},
  volume={4},
  pages={189 - 204}
}
  • L. Liu, T. Cheung, +5 authors T. Rando
  • Published 2013
  • Biology, Medicine
  • Cell reports
  • Summary The ability to maintain quiescence is critical for the long-term maintenance of a functional stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem cells and how they change with age remain largely unknown. In this study, we explore the chromatin features of adult skeletal muscle stem cells, or satellite cells (SCs), which reside predominantly in a quiescent state in fully developed limb muscles of both young and aged mice. Using a ChIP-seq… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 84 REFERENCES
    Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage.
    • 166
    • Highly Influential
    • Open Access
    Maintenance of muscle stem cell quiescence by microRNA-489
    • 333
    • Open Access
    Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • 2,352
    • Open Access
    The Transcriptional and Epigenomic Foundations of Ground State Pluripotency
    • 679
    • Highly Influential
    • Open Access
    A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
    • 4,505
    • Highly Influential
    • Open Access
    The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion.
    • 321
    • Open Access
    Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex
    • 296
    • Open Access
    The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
    • 281
    • Open Access
    Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • 3,790
    • Highly Influential
    • Open Access