Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

@inproceedings{Liu2013ChromatinMA,
  title={Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging},
  author={Ling Liu and Tom Hiu Cheung and Gregory W Charville and Bernadette Marie Ceniza Hurgo and Tripp Leavitt and Johnathan Shih and Anne Brunet and Thomas A Rando},
  booktitle={Cell reports},
  year={2013}
}
The ability to maintain quiescence is critical for the long-term maintenance of a functional stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem cells and how they change with age remain largely unknown. In this study, we explore the chromatin features of adult skeletal muscle stem cells, or satellite cells (SCs), which reside predominantly in a quiescent state in fully developed limb muscles of both young and aged mice. Using a ChIP-seq approach to… CONTINUE READING
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