Chromatin Landscape Dictates HSF Binding to Target DNA Elements

@inproceedings{Guertin2010ChromatinLD,
  title={Chromatin Landscape Dictates HSF Binding to Target DNA Elements},
  author={Michael J. Guertin and John T Lis},
  booktitle={PLoS genetics},
  year={2010}
}
Sequence-specific transcription factors (TFs) are critical for specifying patterns and levels of gene expression, but target DNA elements are not sufficient to specify TF binding in vivo. In eukaryotes, the binding of a TF is in competition with a constellation of other proteins, including histones, which package DNA into nucleosomes. We used the ChIP-seq assay to examine the genome-wide distribution of Drosophila Heat Shock Factor (HSF), a TF whose binding activity is mediated by heat shock… CONTINUE READING

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