Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes

  title={Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes},
  author={Maya Capelson and Yun Liang and Roberta Schulte and William Frederick Mair and Ulrich Wagner and Martin W Hetzer},
Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remains unclear. Here we show that the nucleoporins Sec13, Nup98, and Nup88, as well as a group of FG-repeat nucleoporins, bind to the Drosophila genome at functionally distinct loci that often do not represent nuclear envelope contact sites. Whereas Nup88 localizes to silent loci, Sec13, Nup98, and a subset of FG-repeat nucleoporins bind to… CONTINUE READING
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