Chromatin-Associated RNA Sequencing (ChAR-seq).

  title={Chromatin-Associated RNA Sequencing (ChAR-seq).},
  author={David Jukam and Charles Limouse and Owen K Smith and Viviana I. Risca and Jason C Bell and Aaron F Straight},
  journal={Current protocols in molecular biology},
  volume={126 1},
RNA is a fundamental component of chromatin. Noncoding RNAs (ncRNAs) can associate with chromatin to influence gene expression and chromatin state; many also act at long distances from their transcriptional origin. Yet we know almost nothing about the functions or sites of action for most ncRNAs. Current methods to identify sites of RNA interaction with the genome are limited to the study of a single RNA at a time. Here we describe a protocol for ChAR-seq, a strategy to identify all chromatin… CONTINUE READING
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