Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.

Abstract

Transcriptionally silent genes can be marked by histone modifications and regulatory proteins that indicate the genes' potential to be activated. Such marks have been identified in pluripotent cells, but it is unknown how such marks occur in descendant, multipotent embryonic cells that have restricted cell fate choices. We isolated mouse embryonic endoderm… (More)
DOI: 10.1126/science.1202845

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