Choriodecidual Group B Streptococcal Infection Induces miR-155-5p in the Fetal Lung in Macaca nemestrina.

@article{McAdams2015ChoriodecidualGB,
  title={Choriodecidual Group B Streptococcal Infection Induces miR-155-5p in the Fetal Lung in Macaca nemestrina.},
  author={Ryan Michael McAdams and Craig J Bierle and Erica Boldenow and Samantha Weed and Jesse M. Tsai and Richard P. Beyer and James W. MacDonald and Theo K. Bammler and H. Denny Liggitt and Federico M. Farin and Jeroen P. Vanderhoeven and Lakshmi Rajagopal and Kristina M Adams Waldorf},
  journal={Infection and immunity},
  year={2015},
  volume={83 10},
  pages={3909-17}
}
The mechanisms underlying fetal lung injury remain poorly defined. MicroRNAs (miRNAs) are small noncoding, endogenous RNAs that regulate gene expression and have been implicated in the pathogenesis of lung disease. Using a nonhuman primate model of choriodecidual infection, we sought to determine if differentially expressed miRNAs were associated with acute fetal lung injury. After inoculating 10 chronically catheterized pregnant monkeys (Macaca nemestrina) with either group B streptococcus… CONTINUE READING
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