Choreic movements in the macaque monkey induced by kainic acid lesions of the striatum combined with L-dopa. Pharmacological, biochemical and physiological studies on neural mechanisms.

@article{Kanazawa1990ChoreicMI,
  title={Choreic movements in the macaque monkey induced by kainic acid lesions of the striatum combined with L-dopa. Pharmacological, biochemical and physiological studies on neural mechanisms.},
  author={Ichiro Kanazawa and Minoru Kimura and Miho Murata and Yoshino Tanaka and F Cho},
  journal={Brain : a journal of neurology},
  year={1990},
  volume={113 ( Pt 2)},
  pages={509-35}
}
In order to produce choreic movements in monkeys (Macaca species), we have used the combination of unilateral kainic acid injections into the striatum and the systemic administration of L-DOPA. Two control monkeys received kainic acid injections alone and 7 were also given L-DOPA (150-300 mg/day) orally. No spontaneous involuntary movements were seen after kainic acid injection alone (over a period of 4-14 days). In the 7 monkeys that received L-DOPA 4-7 days after the kainic acid injection, in… CONTINUE READING