Chorea‐ballism associated with familial amyotrophic lateral sclerosis. A clinical, genetic, and neuropathological study

  title={Chorea‐ballism associated with familial amyotrophic lateral sclerosis. A clinical, genetic, and neuropathological study},
  author={Josep G{\'a}mez and Marc Corbera-Bellalta and Montserrat Mil{\'a} and Rosa L{\'o}pez-Lisbona and Susana Boluda and Isidre Ferrer},
  journal={Movement Disorders},
Hyperkinetic movements in amyotrophic lateral sclerosis (ALS) are extremely rare. We present clinical, neuropathological, and genetic data for a 53‐year‐old woman with spinal onset ALS presenting chorea affecting the face, mouth, neck, and hands, and ballism in both arms 31 months after leg weakness onset. Her father and older sister had ALS, but had no movement disorders. As well as the typical neuropathological findings of ALS (marked upper and lower motor neuron loss), post‐mortem… 
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