Chordomas with malignant spindle cell components. A DNA flow cytometric and immunohistochemical study with histogenetic implications.


The authors studied four chordomas with malignant spindle cell components (SCs) and 12 conventional chordomas (CCs) by DNA flow cytometry using paraffin-embedded tissue. In addition, immunohistochemical stains for a variety of epithelial and mesenchymal markers were performed. The four SCs contained areas histologically identical to conventional chordomas… (More)


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