Chopping Out CHOP Chops the Fate of Neurons.

@article{Boison2013ChoppingOC,
  title={Chopping Out CHOP Chops the Fate of Neurons.},
  author={Detlev Boison},
  journal={Epilepsy currents},
  year={2013},
  volume={13 5},
  pages={219-20}
}
Commentary We all seem to know that " seizures beget seizures, " but do we really know why? Seizure-induced neuronal cell death may play a contributing role under certain circumstances (1, 2), and a variety of endogenous neuroprotective mechanisms are in place to limit neuronal injury (3–5). Neuronal cell loss in epilepsy is not straightforward and can depend upon spatial patterns, cell types, and timing of pathways that can either promote or reduce injury (3). Prolonged seizures are thought to… CONTINUE READING

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Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
EpilepsyIs related toSeizures
Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
SeizuresIs related toEpilepsy
Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
SeizuresMapped fromEpilepsy
Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
Since CHOP expression in the hippocampus is induced by seizures ( 9 ) , the question arises whether this increase promotes neuronal cell death in epilepsy or whether an increase in CHOP is an adaptive response to limit neuronal cell loss .
ERBB2 geneGene encodes gene productERBB2 protein, human
Likewise , CHOP expression was found to be increased in all subfields of the hippocampus 8 hours following a seizure preconditioning stimulus — a well - established neu - roprotective strategy — or 8 hours after combining the SE … .
Prolonged seizures are thought to induce excessive glutamate receptor activation , leading to the disruption of intracellular calcium homeostasis , oxidative stress , DNA damage , and dysfunction of intracellular organ - elles — among which , the unfolded protein response and associated endoplasmic reticulum stress might play a crucial role .
Prolonged seizures are thought to induce excessive glutamate receptor activation , leading to the disruption of intracellular calcium homeostasis , oxidative stress , DNA damage , and dysfunction of intracellular organ - elles — among which , the unfolded protein response and associated endoplasmic reticulum stress might play a crucial role .
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