Chop Deficiency Protects Mice Against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macrophage Production.

@article{Yao2016ChopDP,
  title={Chop Deficiency Protects Mice Against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macrophage Production.},
  author={Yingying Yao and Yi Wang and Zhijun Zhang and Long He and Jianghui Zhu and Meng Zhang and Xiaoyu He and Zhenshun Cheng and Qi-lin Ao and Yong Cao and Ping Yang and Yunchao Su and Jianping Zhao and Shuhong Zhang and Qilin Yu and Xiaoyang Wan and Xudong Xiang and Weining Xiong and Congyi Wang and Yongjian Xu},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2016},
  volume={24 5},
  pages={915-25}
}
C/EBP homologous protein (Chop) has been shown to have altered expression in patients with idiopathic pulmonary fibrosis (IPF), but its exact role in IPF pathoaetiology has not been fully addressed. Studies conducted in patients with IPF and Chop(-/-) mice have dissected the role of Chop and endoplasmic reticulum (ER) stress in pulmonary fibrosis pathogenesis. The effect of Chop deficiency on macrophage polarization and related signalling pathways were investigated to identify the underlying… CONTINUE READING
15 Citations
36 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…