Choosing the right medication for the treatment of alcoholism

@article{Pettinati2006ChoosingTR,
  title={Choosing the right medication for the treatment of alcoholism},
  author={H. Pettinati and Amanda R. Rabinowitz},
  journal={Current Psychiatry Reports},
  year={2006},
  volume={8},
  pages={383-388}
}
In the past decade, scientists have made important progress toward understanding the neurobiology underlying an alcohol disorder. This knowledge has led to the development of promising pharmacotherapies that target the neural pathways involved in the brain’s reward center in such a way that the usual treatment response (via counseling) is substantially improved upon. There are now four US Food and Drug Administration (FDA)-approved pharmacotherapies for the treatment of alcohol dependence… Expand
Pharmacotherapy of Alcohol Dependence
TLDR
Pharmacotherapy is being investigated to enhance abstinence and prevent relapse and complement interventions at a psychosocial level to develop clinically useful pharmacological treatments, which can be evaluated using large-scale clinical trials. Expand
Pharmacotherapy of Addictive Disorders
TLDR
Although no pharmacotherapies are currently approved for cocaine addiction, promising lines of research include agents that affect dopaminergic, GABAergic, serotonergic, and glutamatergic systems as well as the promise for immune therapies. Expand
Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics.
TLDR
A critical review of the literature on naltrexone as a pharmacotherapy for alcoholism is provided, which has the potential to identify responders on the basis of genetic variation and to use genetic tools to individualize the use of this medication. Expand
State-of-the-art behavioral and pharmacological treatments for alcohol use disorder
TLDR
None of the treatments reviewed herein represents a so-called silver bullet for AUD, but they each have the potential to significantly improve the odds of recovery. Expand
Neuroimaging in alcohol use disorder: From mouse to man.
TLDR
Together, such in vivo imaging tools have expanded the understanding of the dynamic course of alcoholism including evidence for regional specificity of the effects of AUD, hints at mechanisms underlying the shift from casual to compulsive use of alcohol, and profound recovery with sustained abstinence. Expand
Survey of Addiction Specialists’ Use of Medications to Treat Alcohol Use Disorder
TLDR
Compared with a survey published in 2001, in 2018 the proportion of respondents who reported using naltrexone more than doubled and addiction specialists were more confident in their use of AUD medications, rating their efficacy and safety more highly. Expand
State-ofthe-art behavioral and pharmacological treatments for alcohol use disorder
Background: Alcohol use disorder (AUD) and its associated consequences remain significant public health concerns. Given that AUD represents a spectrum of severity, treatment options represent aExpand
Treatment of alcohol dependence in patients with co-morbid major depressive disorder – predictors for the outcomes with memantine and escitalopram medication
BackgroundAlcohol dependence comorbid with major depressive disorder poses a major challenge in the clinical setting. The results in the treatment with selective serotonin re-uptake inhibitors haveExpand
Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence
TLDR
The results suggest that naltrexone might be particularly beneficial for improving alcohol use outcomes in alcohol-dependent smokers. Expand
Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence
TLDR
Data collected by the laboratory showing that one neurosteroid in particular, dehydroepiandrosterone (DHEA), decreases ethanol intake in rats under a variety of conditions is presented. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 38 REFERENCES
The Status of Disulfiram: A Half of a Century Later
TLDR
Preliminary evidence suggests that disulfiram treatment could be a viable treatment for cocaine dependence because it was shown to reduce cocaine use among nonalcoholic, cocaine-dependent patients. Expand
Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis.
TLDR
Both naltrexone and acamprosate are efficacious in reducing alcohol consumption in alcoholics, however, their specific role in alcoholism treatment remains to be more clearly defined. Expand
Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial.
TLDR
Motivated individuals with moderate alcohol dependence can be treated with greater effectiveness when naltrexone is used in conjunction with weekly outpatient cognitive behavioral therapy. Expand
Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.
TLDR
Patients receiving medical management with naltrexone, CBI, or both fared better on drinking outcomes, whereas acamprosate showed no evidence of efficacy, with or without CBI. Expand
Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivation.
TLDR
The US study findings suggest that acamprosate is safe and well tolerated in a broadly inclusive sample of alcoholics and appears effective in populations of patients motivated to have a treatment goal of abstinence. Expand
Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial.
TLDR
This is the first multicenter study of a depot formulation of naltrexone for the treatment of alcohol dependence and using a conservative intent-to-treat analysis, the study showed an advantage for the active medication. Expand
Antidepressant treatment of co-occurring depression and alcohol dependence
TLDR
The findings from this review better define the action of antidepressants in patients with co-occurring depression and alcohol dependence as specific to reducing depressive symptoms, and these medications and their action on mood have little impact on treating the co-Occurring alcohol dependence. Expand
Naltrexone in the treatment of alcoholism: a clinical review.
TLDR
It is concluded that naltrexone is a safe and useful adjunct in the rehabilitation of alcohol-dependent patients and may be improved by designing a treatment program that enhances compliance with the medication. Expand
Oral topiramate for treatment of alcohol dependence: a randomised controlled trial
TLDR
Topiramate (up to 300 mg per day) is more efficacious than placebo as an adjunct to standardised medication compliance management in treatment of alcohol dependence. Expand
Predicting treatment response to naltrexone: the influence of craving and family history.
TLDR
The data suggest that patients with high levels of alcohol craving or a strong family history of alcoholism are more likely to benefit from naltrexone treatment. Expand
...
1
2
3
4
...