• Corpus ID: 20655086

Choosing a skeletal muscle relaxant.

@article{See2008ChoosingAS,
  title={Choosing a skeletal muscle relaxant.},
  author={Sharon See and Regina Ginzburg},
  journal={American family physician},
  year={2008},
  volume={78 3},
  pages={
          365-70
        }
}
Skeletal muscle relaxants are widely used in treating musculoskeletal conditions. However, evidence of their effectiveness consists mainly of studies with poor methodologic design. In addition, these drugs have not been proven to be superior to acetaminophen or nonsteroidal anti-inflammatory drugs for low back pain. Systematic reviews and meta-analyses support using skeletal muscle relaxants for short-term relief of acute low back pain when nonsteroidal anti-inflammatory drugs or acetaminophen… 

Tables from this paper

Antispasmodics and Muscle Relaxants
TLDR
Most guidelines and current evidence support short-term use for all medications discussed in this chapter, and there is no clear evidence to show superiority of one muscle relaxant over another in managing acute low back pain.
Evidências sobre relaxantes musculares de uso ambulatorial: Uma revisão da literatura
TLDR
Muscle relaxants in general compared to placebo or to each other showed little evidence with significant statistics, therefore the drug selection should be based on the profile of adverse effects, patient preference, potential of abuse, Potential of interaction with other drugs, cost and other characteristics of the drugs.
Efficacy and tolerability of muscle relaxants for low back pain: Systematic review and meta‐analysis
TLDR
Five trials provide high quality evidence that muscle relaxants provide clinically significant pain relief in the short term for acute LBP, and there was no eligible RCT evidence to support the efficacy of benzodiazepines in LBP.
The Safety and Efficacy of Methocarbamol as a Muscle Relaxant with Analgesic Action: Analysis of Current Data
TLDR
Methocarbamol has proven to be an effective and safe drug for use as a supplement to exercise regimen, physiotherapy and other activities to ease the discomfort associated with acute musculoskeletal disorders.
Muscle Relaxant Use Among Hemodialysis Patients: Prevalence, Clinical Indications, and Adverse Outcomes.
TLDR
Muscle relaxant use was common in hemodialysis patients and associated with altered mental status and falls and the lower risk for death with muscle relaxants may have been the result of residual confounding.
Opioid and Non-opioid Therapy
TLDR
Although there is still insufficient evidence to recommend cannabinoids for spine pain treatment, this chapter discusses this emerging medication class because it has been already used to treat certain pain conditions.
Acute back pain: benefits and risks of current treatments
  • B. Mccarberg
  • Medicine
    Current medical research and opinion
  • 2010
TLDR
A wide range of treatments is currently recommended for the management of patients with acute back pain and all are supported by results from controlled clinical trials, which support the view that both NSAIDs and low-level continuous heat treatment are more effective than acetaminophen.
Utilization patterns of skeletal muscle relaxants among commercially insured adults in the United States from 2006 to 2018.
TLDR
The considerable growth in the use of baclofen, tizanidine, and methocarbamol paralleled with a decline in carisoprodol and metaxalone use and trends varied among individual agents, patient groups, and geographic regions.
Signals of Muscle Relaxant Drug Interactions Associated with Unintentional Traumatic Injury: A Population-Based Screening Study
TLDR
Using real-world data, several new signals of potential muscle relaxant drug interactions associated with unintentional traumatic injury are identified and one among 16 signals is currently reported in a major drug interaction knowledge base.
Risk for Fractures with Centrally Acting Muscle Relaxants: An Analysis of a National Medicare Advantage Claims Database
TLDR
Evidence of an association between the risk of fractures and the use of centrally acting muscle relaxants in older adults is provided, which supports current recommendations advising extreme caution in prescribing muscle Relaxants to older adults.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
A Clinical and Pharmacologic Review of Skeletal Muscle Relaxants for Musculoskeletal Conditions
TLDR
Only a limited number of high-quality, randomized, controlled trials (RCTs) provide evidence of the effectiveness of NSAIDs or SMRs in the treatment of acute, uncomplicated MSDs, and remarkably little sound science guides the choice of drug.
Double-blind study of metaxalone; use as skeletal-muscle relaxant.
TLDR
Patients with an acute skeletal-muscle spasm frequently pose a considerable problem to the practitioner who must deal with these spastic conditions and hence they seek medical attention for the purpose of shortening the acute phase of the disease.
Muscle relaxants for non-specific low back pain.
TLDR
There is strong evidence that any of these muscle relaxants are more effective than placebo for patients with acute LBP on short-term pain relief, but the adverse effects require that they be used with caution.
Prescription of Nonsteroidal Anti-inflammatory Drugs and Muscle Relaxants for Back Pain in the United States
TLDR
Examination of national prescription patterns of nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants among individuals with back pain in the United States found several individual characteristics including age, race, and educational level were associated with the prescription of some of the medications.
Cyclobenzaprine and naproxen versus naproxen alone in the treatment of acute low back pain and muscle spasm.
TLDR
It is demonstrated that patients with muscle spasm associated with acute low back strain benefited from the use of combination therapy consisting of a nonsteroidal anti-inflammatory agent (naproxen) and a muscle relaxant (cyclobenzaprine).
Cyclobenzaprine hydrochloride effect on skeletal muscle spasm in the lumbar region and neck: two double-blind controlled clinical and laboratory studies.
  • J. Basmajian
  • Medicine
    Archives of physical medicine and rehabilitation
  • 1978
TLDR
With improvement, myoelectric activity in back muscles is augmented during prescribed stressful movements as measured by electromyography and computer analysis combined with complex electrogoniometry.
Cyclobenzaprine in intractable pain syndromes with muscle spasm.
The effectiveness of cyclobenzaprine hydrochloride, a new tricyclic skeletal muscle relaxant, was shown in patients with long-term intractable pain of cervical and lumbar origin aggravated by
...
1
2
3
...