Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats

@article{Vandaele2016ChoosingUT,
  title={Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats},
  author={Youna Vandaele and Lauriane Cantin and Fuschia Serre and Caroline Vouillac-Mendoza and Serge H. Ahmed},
  journal={Neuropsychopharmacology},
  year={2016},
  volume={41},
  pages={646-657}
}
Ample evidence shows that the setting can control drug choices in both humans and animals. Here we reveal in rats that a major mechanism of this control involves a regulation of the drug influence on other competing options at the time of choice. Briefly, rats were offered a choice between a drug dose (cocaine or heroin) and a brief access to water sweetened with saccharin in two different settings. In one setting, choosing under the influence was not possible and rats largely preferred… CONTINUE READING
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