Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo.

Abstract

OBJECTIVE To investigate the direct effect of prolyl-hydroxyproline (Pro-Hyp) on chondrocytes under in vivo and in vitro conditions in an attempt to identify Pro-Hyp as the bioactive peptide in collagen hydrolysate (CH). METHODS The in vivo effects of CH and Pro-Hyp intake on articular cartilage were studied by microscopic examination of sections of… (More)
DOI: 10.1016/j.joca.2009.07.001

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