Chondroitinase gene therapy improves upper limb function following cervical contusion injury

@article{James2015ChondroitinaseGT,
  title={Chondroitinase gene therapy improves upper limb function following cervical contusion injury},
  author={Nicholas D James and Jessie R. Shea and Elizabeth Muir and Joost Verhaagen and Bernard L Schneider and Elizabeth J. Bradbury},
  journal={Experimental Neurology},
  year={2015},
  volume={271},
  pages={131-135}
}
Chondroitin sulphate proteoglycans (CSPGs) are known to be important contributors to the intensely inhibitory environment that prevents tissue repair and regeneration following spinal cord injury. The bacterial enzyme chondroitinase ABC (ChABC) degrades these inhibitory molecules and has repeatedly been shown to promote functional recovery in a number of spinal cord injury models. However, when used to treat more traumatic and clinically relevant spinal contusion injuries, findings with the… CONTINUE READING
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