Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain.

@article{Lin2008ChondroitinaseAH,
  title={Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain.},
  author={Rachel H C Lin and Jessica C F Kwok and D{\'a}maso Crespo and James W. Fawcett},
  journal={Journal of neurochemistry},
  year={2008},
  volume={104 2},
  pages={400-8}
}
Chondroitin sulphate proteoglycans (CSPGs) are axon growth inhibitory molecules present in the glial scar that play a part in regeneration failure after damage to the CNS and which restrict CNS plasticity. Removal of chondroitin sulphate glycosaminoglycan (GAG) chains with chondroitinase-ABC (chABC) in models of CNS injury promotes both axon regeneration and plasticity. We have analysed the immediate and long-term effects of a single injection of chABC on CSPGs, GAGs and axon regeneration. We… CONTINUE READING