Chondroitin sulphate proteoglycans in the central nervous system: changes and synthesis after injury.

@article{Properzi2003ChondroitinSP,
  title={Chondroitin sulphate proteoglycans in the central nervous system: changes and synthesis after injury.},
  author={Francesca Properzi and R A Asher and James W. Fawcett},
  journal={Biochemical Society transactions},
  year={2003},
  volume={31 2},
  pages={
          335-6
        }
}
Chondroitin sulphate proteoglycans (CSPGs) are up-regulated in the central nervous system after injury, specifically around the lesion site where the glial scar forms. This structure contains astrocytes, oligodendrocyte precursor cells, microglia and meningeal cells, and forms an inhibitory substrate for axon re-growth. CSPGs have been shown to be closely involved in this neuronal growth inhibition, specifically through their sugar chains. These chains are composed of repeats of the same… CONTINUE READING

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