Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation.

@article{Lemons1999ChondroitinSP,
  title={Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation.},
  author={Michele L. Lemons and Dena R Howland and Douglas K. Anderson},
  journal={Experimental neurology},
  year={1999},
  volume={160 1},
  pages={51-65}
}
Extrinsic factors appear to contribute to the lack of regeneration in the injured adult spinal cord. It is likely that these extrinsic factors include a group of putative growth inhibitory molecules known as chondroitin sulfate proteoglycans (CSPGs). The aims of this study were to determine: (1) the consequences of spinal cord contusion injury on CSPG expression, (2) if CSPGs can be degraded in vivo by exogenous enzyme application, and (3) the effects of intraspinal transplantation on the… CONTINUE READING
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