Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development

@inproceedings{Watanabe2010ChondroitinSN,
  title={Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development},
  author={Yumi Watanabe and Kosei Takeuchi and Susumu Higa Onaga and Michiko Sato and Mika Tsujita and Manabu Abe and Rie Natsume and Minqi Li and Tatsuya Furuichi and Mika Saeki and Tomomi Izumikawa and Ayumi Hasegawa and Minesuke Yokoyama and Shiro Ikegawa and Kenji Sakimura and Norio Amizuka and Hiroshi Kitagawa and Michihiro Igarashi},
  booktitle={The Biochemical journal},
  year={2010}
}
CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice. CS production was reduced by approximately half in CSGalNAcT1-null mice, and the amount of short-chain CS was also reduced. Moreover, the cartilage of the null mice was significantly smaller than that of wild-type mice. Additionally… CONTINUE READING
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