Chondroitin sulfate disrupts axon pathfinding in the optic tract and alters growth cone dynamics.

@article{Walz2002ChondroitinSD,
  title={Chondroitin sulfate disrupts axon pathfinding in the optic tract and alters growth cone dynamics.},
  author={Andreas Walz and Richard B. Anderson and Atsushi Irie and Chi-Bin Chien and Christine E Holt},
  journal={Journal of neurobiology},
  year={2002},
  volume={53 3},
  pages={
          330-42
        }
}
Little is known about the cues that guide retinal axons across the diencephalon en route to their midbrain target, the optic tectum. Here we show that chondroitin sulfate proteoglycans are differentially expressed within the diencephalon at a time when retinal axons are growing within the optic tract. Using exposed brain preparations, we show that the addition of exogenous chondroitin sulfate results in retinal pathfinding errors. Retinal axons disperse widely from their normal trajectory… CONTINUE READING

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