Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells.

@article{Sugahara2008ChondroitinSE,
  title={Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells.},
  author={Kazuki N. Sugahara and Takako Hirata and Toshiyuki Tanaka and Shinji Ogino and Mitsuhiro Takeda and Hiroaki Terasawa and Ichio Shimada and Jun-ichi Tamura and Gerdy B. ten Dam and Toin H. van Kuppevelt and Masayuki Miyasaka},
  journal={Cancer research},
  year={2008},
  volume={68 17},
  pages={7191-9}
}
During tumor cell invasion, certain extracellular matrix (ECM) components such as hyaluronan (HA) are degraded into small oligosaccharides, which are detected in patients. We previously reported that such HA oligosaccharides induce the proteolytic cleavage of an ECM-binding molecule CD44 from tumor cells and promote tumor cell migration in a CD44-dependent… CONTINUE READING