Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains in the Development of Cerebellum

  title={Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains in the Development of Cerebellum},
  author={Chie Mitsunaga and Tadahisa Mikami and Shuji Mizumoto and Junko Fukuda and Kazuyuki Sugahara},
  journal={Journal of Biological Chemistry},
  pages={18942 - 18952}
Chondroitin sulfate/dermatan sulfate (CS/DS) chains regulate the development of the central nervous system in vertebrates. Previously, we demonstrated that CS/DS hybrid chains from embryonic pig brain exhibit neuritogenic and growth factor binding activities, which depended on their IdoUA content defining the DS-like structure. To elucidate the distribution of such functional sugar chains during the development of the brain, in situ hybridization was performed to examine expression of three CS… 

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