Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains in the Development of Cerebellum

@article{Mitsunaga2006ChondroitinSS,
  title={Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains in the Development of Cerebellum},
  author={Chie Mitsunaga and Tadahisa Mikami and Shuji Mizumoto and Junko Fukuda and Kazuyuki Sugahara},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={18942 - 18952}
}
Chondroitin sulfate/dermatan sulfate (CS/DS) chains regulate the development of the central nervous system in vertebrates. Previously, we demonstrated that CS/DS hybrid chains from embryonic pig brain exhibit neuritogenic and growth factor binding activities, which depended on their IdoUA content defining the DS-like structure. To elucidate the distribution of such functional sugar chains during the development of the brain, in situ hybridization was performed to examine expression of three CS… 

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Seven novel hexasaccharide sequences, in addition to three previously reported sequences, were isolated after exhaustive digestion of the CS chains with the chondroitin lyase AC-I, which cannot act on galactosaminidic linkages adjacent to the D-units.
Structural and functional changes of sulfated glycosaminoglycans in Xenopus laevis during embryogenesis.
TLDR
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