Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains in the Development of Cerebellum

@article{Mitsunaga2006ChondroitinSS,
  title={Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains in the Development of Cerebellum},
  author={Chie Mitsunaga and Tadahisa Mikami and Shuji Mizumoto and Junko Fukuda and Kazuyuki Sugahara},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={18942 - 18952}
}
Chondroitin sulfate/dermatan sulfate (CS/DS) chains regulate the development of the central nervous system in vertebrates. Previously, we demonstrated that CS/DS hybrid chains from embryonic pig brain exhibit neuritogenic and growth factor binding activities, which depended on their IdoUA content defining the DS-like structure. To elucidate the distribution of such functional sugar chains during the development of the brain, in situ hybridization was performed to examine expression of three CS… 
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Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain.
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The results suggest that the IdoA-containing structures in the developing brain are mainly produced by the actions of DS-epi2 and play crucial roles in postnatal development.
Analysis of the structure and neuritogenic activity of chondroitin sulfate/dermatan sulfate hybrid chains from porcine fetal membranes
TLDR
The structure and bioactivity of the CS/DS chains from porcine fetal membranes (FM-CS/DS) were investigated and showed neurite outgrowth-promoting activity, which was suppressed by antibodies against growth factors including pleiotrophin, midkine, and fibroblast growth factor-2, suggesting the involvement of these growth factors in the neuriteOutgrowth- Promoting activity.
Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: insights into the sugar sequences with bioactivities.
TLDR
Hexasaccharides containing two consecutive D-units or a B-unit will be useful for the structural and functional analyses of CS chains particularly in the neuroglycobiological fields.
Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish.
TLDR
The results suggest that 4-O-sulfated CS formed by C4ST-1 is essential for somitic muscle differentiation and motor axon guidance in zebrafish development.
Oversulfated Chondroitin Sulfate Plays Critical Roles in the Neuronal Migration in the Cerebral Cortex*
TLDR
Examination of the expression and function of three CS sulfotransferases in the developing neocortex revealed that specific oversulfated structures in CS chains play critical roles in the migration of neuronal precursors during cortical development.
Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration
The roles of chondroitin-4-sulfotransferase-1 in development and disease.
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  • 2010
Novel chondroitin sulfate oligosaccharide motifs as biomarkers: insights into their involvement in brain development.
  • K. Sugahara
  • Biology, Chemistry
    Advances in experimental medicine and biology
  • 2015
TLDR
Seven novel hexasaccharide sequences, in addition to three previously reported sequences, were isolated after exhaustive digestion of the CS chains with the chondroitin lyase AC-I, which cannot act on galactosaminidic linkages adjacent to the D-units.
Structural and functional changes of sulfated glycosaminoglycans in Xenopus laevis during embryogenesis.
TLDR
GAGs bound growth factors including fibroblast growth factors-1 and -2, midkine, and pleiotrophin, with comparable affinities significantly varied during development, although the correlation between the structural alterations of GAGs and the change in the ability to bind growth factors remains to be clarified.
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