Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations.

@article{Somoza2014ChondrogenicDO,
  title={Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations.},
  author={Rodrigo A. Somoza and Jean F. Welter and Diego Augusto Leme Correa and Arnold I Caplan},
  journal={Tissue engineering. Part B, Reviews},
  year={2014},
  volume={20 6},
  pages={596-608}
}
Articular cartilage repair and regeneration provides a substantial challenge in Regenerative Medicine because of the high degree of morphological and mechanical complexity intrinsic to hyaline cartilage due, in part, to its extracellular matrix. Cartilage remains one of the most difficult tissues to heal; even state-of-the-art regenerative medicine technology cannot yet provide authentic cartilage resurfacing. Mesenchymal stem cells (MSCs) were once believed to be the panacea for cartilage… CONTINUE READING

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