Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.

@article{Wei2012ChondrogenicDO,
  title={Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.},
  author={Yiyong Wei and Wei-ping Zeng and Rui Wan and J Wang and Qian Zhou and Songbo Qiu and Shree Ram Singh},
  journal={European cells & materials},
  year={2012},
  volume={23},
  pages={1-12}
}
Induced pluripotent stem cells (iPSCs) have the potential to revolutionise cell therapy; however, it remains unclear whether iPSCs can be generated from human osteoarthritic chondrocytes (OCs) and subsequently induced to differentiate into chondrocytes. In the present study, we investigated the differentiation potential of OCs into iPSCs using defined transcription factors and explored the possibility of using these OC-derived iPSCs for chondrogenesis. Our study demonstrates that iPSCs can be… CONTINUE READING
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Induced pluripotent stem cells: opportunities and challenges.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2011
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