Chondrogenic differentiation of human mesenchymal stem cells cultured in a cobweb-like biodegradable scaffold.

@article{Chen2004ChondrogenicDO,
  title={Chondrogenic differentiation of human mesenchymal stem cells cultured in a cobweb-like biodegradable scaffold.},
  author={Guoping Chen and Dechang Liu and Mika Tadokoro and Rei Hirochika and Hajime Ohgushi and Junzo Tanaka and Tetsuya Tateishi},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={322 1},
  pages={50-5}
}
Human mesenchymal stem cells (MSCs) were cultured in vitro in a cobweb-like biodegradable polymer scaffold: a poly(dl-lactic-co-glycolic acid)-collagen hybrid mesh in serum-free DMEM containing TGF-beta3 for 1-10 weeks. The cells adhered to the hybrid mesh, distributed evenly, and proliferated to fill the spaces in the scaffold. The ability of the cells to express gene encoding type I collagen decreased, whereas its ability to express type II collagen and aggrecan increased. Histological… CONTINUE READING

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