Chondrogenic and osteogenic differentiations of human bone marrow-derived mesenchymal stem cells on a nanofibrous scaffold with designed pore network.

@article{Hu2009ChondrogenicAO,
  title={Chondrogenic and osteogenic differentiations of human bone marrow-derived mesenchymal stem cells on a nanofibrous scaffold with designed pore network.},
  author={Jiang Lei Hu and Kai D. Feng and Xiaohua Liu and Peter X Ma},
  journal={Biomaterials},
  year={2009},
  volume={30 28},
  pages={
          5061-7
        }
}
The utilization of 3D scaffolds and stem cells is a promising approach to solve the problem of bone and cartilage tissue shortage and to construct osteochondral (cartilage/bone composite) tissues. In this study, 3D highly porous nanofibrous (NF) poly(L-lactic acid) (PLLA) scaffolds fabricated using a phase separation technique were seeded with multi-potent human bone marrow-derived mesenchymal stem cells (hMSCs) and the constructs were induced along osteogenic and chondrogenic development… CONTINUE READING

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