Chondrogenesis: a model developmental system for measuring teratogenic potential of compounds.

  title={Chondrogenesis: a model developmental system for measuring teratogenic potential of compounds.},
  author={J. Hassell and Elizabeth A. Horigan},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  volume={2 3-4},
A simple test for determining the teratogenic potential of compounds is described using embryonic limb bud cells in culture. These mesenchyme cells multiply and differentiate into chondrocytes during a 6-day culture period. The extent of chondrogenesis is assessed by staining for the cartilage specific proteoglycan with alcian blue. The amount of stain is then measured spectrophotometrically. Compounds which interfere with growth or differentiation reduce the amount of proteoglycan and as a… CONTINUE READING

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