Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2.

@article{Saito2014ChondrocytePR,
  title={Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2.},
  author={Atsushi Saito and Soshi Kanemoto and Yizhou Zhang and Rie Asada and Kenta Hino and Kazunori Imaizumi},
  journal={Molecular cell},
  year={2014},
  volume={53 1},
  pages={127-39}
}
The endoplasmic reticulum (ER) stress transducer BBF2H7/CREB3L2 is an ER-resident transmembrane transcription factor. In response to physiological ER stress, it is processed at the transmembrane region to generate a cytoplasmic N terminus, which contains a basic leucine zipper (bZIP) domain, and luminal C terminus. The BBF2H7 N terminus functions as a transcription factor to promote the expression of ER-Golgi trafficking-related genes and plays crucial roles in chondrocyte differentiation. Here… CONTINUE READING
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