Chondrocyte proliferation of the cranial base cartilage upon in vivo mechanical stresses.

@article{Wang2002ChondrocytePO,
  title={Chondrocyte proliferation of the cranial base cartilage upon in vivo mechanical stresses.},
  author={Xiaoyan Wang and Jeremy J Mao},
  journal={Journal of dental research},
  year={2002},
  volume={81 10},
  pages={701-5}
}
Whereas the growth of the cranial base cartilage is thought to be regulated solely by genes, epiphyseal growth plates are known to respond to mechanical stresses. This disparity has led to our hypothesis that chondrocyte proliferation is accelerated by mechanical stimuli above natural growth. Two-Newton tensile forces with static and cyclic waveforms were delivered in vivo to the premaxillae of actively growing rabbits for 20 min/day over 12 consecutive days. The average number of BrdU-labeled… CONTINUE READING

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