Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine.
@article{Sandy1998ChondrocytemediatedCO, title={Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine.}, author={J. Sandy and D. Gamett and V. Thompson and C. Verscharen}, journal={The Biochemical journal}, year={1998}, volume={335 ( Pt 1)}, pages={ 59-66 } }
A rat chondrosarcoma cell line and bovine cartilage explants have been used to study the control of aggrecan degradation by chondrocytes treated with interleukin-1 (IL-1) or retinoic acid (RA). Aggrecan fragment analysis with anti-neo-epitope antibodies suggests that aggrecanase (an as yet unidentified enzyme) is the only aggrecan-degrading proteinase active in these cultures. With rat cells, aggrecanase converts the aggrecan core protein into two major G1-domain-bearing products (60 kDa with a… CONTINUE READING
152 Citations
Chondrocyte-mediated catabolism of aggrecan: evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid.
- Chemistry, Medicine
- Archives of biochemistry and biophysics
- 1999
- 39
The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.
- Medicine
- The Biochemical journal
- 2000
- 36
- PDF
The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1
- Chemistry
- 2000
- 16
10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin.
- Chemistry, Medicine
- Osteoarthritis and cartilage
- 2010
- 10
- Highly Influenced
Expression and Regulation of Aggrecanase in Arthritis: The Role of TGF-β1
- Medicine
- The Journal of Immunology
- 2002
- 141
- PDF
Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants.
- Chemistry, Medicine
- American journal of veterinary research
- 2005
- 85
Aggrecanase-mediated cartilage degradation.
- Chemistry, Medicine
- Current opinion in pharmacology
- 2002
- 162
Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes.
- Chemistry, Medicine
- Osteoarthritis and cartilage
- 2003
- 179