Chondrocyte-derived transglutaminase promotes maturation of preosteoblasts in periosteal bone.

@article{Nurminskaya2003ChondrocytederivedTP,
  title={Chondrocyte-derived transglutaminase promotes maturation of preosteoblasts in periosteal bone.},
  author={Maria V. Nurminskaya and Cordula Magee and Lidia Faverman and Thomas F. Linsenmayer},
  journal={Developmental biology},
  year={2003},
  volume={263 1},
  pages={139-52}
}
During endochondral development, elongation of the bone collar occurs coordinately with growth of the underlying cartilaginous growth plate. Transglutaminases (TGases) are upregulated in hypertrophic chondrocytes, and correlative evidence suggests a relationship between these enzymes and mineralization. To examine whether TGases are involved in regulating mineralization/osteogenesis during bone development, we devised a coculture system in which one cellular component (characterized as… CONTINUE READING
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