Cholinolytics in the treatment of anticholinesterase poisoning. I. The effectiveness of certain cholinolytics in combination with an oxime for treatment of sarin poisoning.

@article{Coleman1962CholinolyticsIT,
  title={Cholinolytics in the treatment of anticholinesterase poisoning. I. The effectiveness of certain cholinolytics in combination with an oxime for treatment of sarin poisoning.},
  author={I. Coleman and P. Little and R. A. Bannard},
  journal={Canadian journal of biochemistry and physiology},
  year={1962},
  volume={40},
  pages={
          815-26
        }
}
  • I. Coleman, P. Little, R. A. Bannard
  • Published 1962
  • Chemistry, Medicine
  • Canadian journal of biochemistry and physiology
  • The protection to sarin poisoning afforded mice by treatment with N-methylpyridinium-2-aldoxime methanesulphonate (P-2-S) in combination with each of 34 cholinolytic compounds used as substitutes for atropine sulphate has been assessed. Twenty-two of the drugs examined in the mouse at a dosage of 50 μmoles/kg gave protection equal to or greater than that afforded by atropine sulphate. The most potent drug was 4′-N-methylpiperidyl 1-phenylcyclopen-tanecarboxylate hydrochloride (G-3063), which… CONTINUE READING
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