Cholinesterases regulation in the absence of ColQ.

  title={Cholinesterases regulation in the absence of ColQ.},
  author={S{\'e}verine M Sigoillot and Francine Bourgeois and Claire Legay},
  journal={Chemico-biological interactions},
  volume={187 1-3},
Normal physiological activity of the neuromuscular junction (NMJ) requires that key molecules are clustered at the synapse. One of these molecules is acetylcholinesterase (AChE) that regulates acetylcholine levels. This enzyme exists under different isoforms but the predominant form at the NMJ is a collagen-tailed enzyme. The collagen associated to AChE (ColQ) fulfills two functions. It anchors and accumulates AChE in the extracellular matrix. Mutations in ColQ lead to faint or no activity of… CONTINUE READING