Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy.

@article{Wilkinson2004CholinesteraseIU,
  title={Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy.},
  author={David G Wilkinson and Paul T Francis and Elias M Schwam and Jennifer Payne-Parrish},
  journal={Drugs & aging},
  year={2004},
  volume={21 7},
  pages={453-78}
}
The deficiency in cholinergic neurotransmission in Alzheimer's disease has led to the development of cholinesterase inhibitors as the first-line treatment for symptoms of this disease. The clinical benefits of these agents include improvements, stabilisation or less than expected decline in cognition, function and behaviour. The common mechanism of action underlying this class of agents is an increase in available acetylcholine through inhibition of the catabolic enzyme, acetylcholinesterase… CONTINUE READING
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