Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease.

  title={Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease.},
  author={Oscar L. Lopez and James T. Becker and Stan Wisniewski and Judith A. Saxton and Daniel I. Kaufer and Steven DeKosky},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={72 3},
OBJECTIVE To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD). METHODS The short and long term effects of CEIs were evaluated in 135 patients with probable Alzheimer's disease relative to 135 patients who were never exposed to CEIs matched by age, education, duration of the symptoms, and cognitive status. We measured 1 year change in cognitive and functional performance, and the likelihood of arriving at each of four end points: (1… CONTINUE READING


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